Glycemic Response of Healthy Adults
to GR2 Control® Meal Replacement Protein Shake,
SlimFast® and a cereal/juice-based breakfast
February 28, 2001
Health Research and Studies Center (HRS), Los Altos, California
Gene A. Spiller, Ph.D., C.N.S.
Statistics by Stanley Morse, Ph.D.
Arianna A. Carughi, Ph.D., C.N.S., SAB Member, GNLD International
Purpose of the study was to compare the changes in serum glucose (glycemic response) induced by GNLD’s Meal Replacement Protein Shake to that induced by a popular, mass market diet drink (SlimFast®) and by a popular cereal/juice-based breakfast.
A total of 12 were enrolled subjects, plus one male who participated as a special subject. One female dropped out after the first test. Subjects had a screening serum glucose test performed at a local clinical laboratory to determine study eligibility. The protocol was reviewed and approved by the HRS independent review committee. Each subject signed an informed consent form and the Subjects’ Bill of Rights.
• 35 to 60 years of age
• no known major health problems or disease
• normal overnight fasting blood sugar levels (less than 105 mg/dL and equal or greater than 70 mg/dL)
Subjects were asked to consume a standard dinner the night before each testing date and came to the Center having fasted for 12 hours. No food or alcohol was allowed after 8:00 p.m. the night before a test. Only water is allowed during the fast and the morning of a test (no coffee, tea, etc.) Subjects must refrain from strenuous exercise the day prior to testing.
Each subject was tested three times: one day per test meal, with a rest period of two weeks between each test day. On the first testing day, all subjects received the regular breakfast (see test meals below). On the second and third testing days, half of the subjects received the SlimFast, and the other half received GNLD’s Meal Replacement Protein Shake in a random sequence.
Subjects’ average age was 48±5 (mean±SD - 40 to 54 years)
• Regular breakfast consisting of 1 serving of cereal with 1% low-fat milk and 6 oz. orange juice
• SlimFast, vanilla flavor, one serving
• GNLD’s vanilla Meal Replacement Protein Shake, one serving
Serum glucose levels were measured at fasting, and then 20, 40, 60, 90 and 120 minutes after the meals were ingested. The test meals were to be consumed within 15 minutes.
Figure 1 - Comparison of serum glucose response for each treatment
As analyzed by Stanley Morse, Ph.D.